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Medical HIV News Briefs

News - Briefly and Links

to summaries from the CDC HIV/STD/TB Prevention News Update, AIDSinfo.nih.gov and aidsmap, a website of NAM a UK-based organization, and links to Kaiser HIV/AIDS Report, The Body, Medscape and other sources including the Journal Watch. See also Medical News on Hepatitis, STDs, and TB. Note: Some links to Journal Watch, published by the New England Journal of Medicine, require registration/subscription.

New HIV/AIDS trials have been added to ClinicalTrials.gov in the last 30 days. For a list of trials click here.
Please send comments or suggestions to ContactUs@aidsinfo.nih.gov

 February News Briefs

NAM Covers 17th Conference on Retroviruses and Opportunistic Infections, San Francisco, USA
16-19 February 2010

The annual Conference on Retroviruses and Opportunistic Infections (CROI) is one of the major conferences of the year for the HIV world. The conference aims to give scientists and doctors an opportunity to share their HIV research, so that the work they do in clinical practice and in laboratories can be turned into progress around the world.
Highlights from this year's conference may include new information on:
• Treatment as prevention
• Hepatitis and HIV co-infection in the developing world
• Heart disease and bone problems in people on long-term treatment
• HIV and the brain: should we worry about long-term effects?
• Cancers in people with HIV
• TB prevention and treatment

NAM is an award-winning, community-based organisation, which works from the UK. We deliver reliable and accurate HIV information across the world to HIV-positive people and to the professionals who treat, support and care for them.

Live Coverage Blog for CROI Launches
The International Foundation for Alternative Research in AIDS (IFARA) launched it blog to provide Live coverage of CROI Press Conferences, on-demand Interviews, Summary Panel discussions in multiple languages and programming for special populations.

CROI - Conference on Retroviruses and Opportunistic Infections – is the pre-eminent conference on the science of AIDS, covering current HIV/AIDS and Hepatitis research peer reviewed by thousands of attendees in poster sessions and convened sessions from February 17-19th 2010 at the Moscone West Convention Center, San Francisco, CA

PRESS CONFERENCES: will be webcast on www.IFARABLOG.org 1pm PT each day at CROI

ON DEMAND INTERVIEWS: Community educators and scholarship recipients of the CROI will interview leading scientists and clinicians presenting data and discussion about the use of anti-HIV and Hepatitis medications being presented and reviewed at the CROI. These interviews should provide a deeper look at the work of the researchers and answer some of the questions one might have about the individuals work.

MAIN PROGRAM: “A LONG LIFE WITH AIDS / UPDATE 2010”. IFARA produces its ninth annual webcast from the Conference on Retroviruses and Opportunistic Infections, “CROI” on February 20th, 2010 (3-5pm ET, 2-4pm CT, 1-3pm MT, noon-2pm PT, 11am-1pm AKT, 10am-Noon HT). The webcast direct from San Francisco will be a two-hour summary of the CROI conference, highlighting new information related to HIV and Hepatitis treatment issues. This multi-panel program is appropriate for medical and non-medical HIV/AIDS providers and informed community, supportive friends and family. To become a host in your city or view the program see above contacts.

PROGRAMMING FOR SPECIAL POPULATIONS: Panel programs hosted by individuals who are best able to present useful information requested by special populations will be presented on Saturday the 20th before and after the MAIN PROGRAM. Focuses: African American, Native American, Women, Aging, Youth, (special language programs) Spanish, French, German, Italian, Russian, Chinese, Japanese.

IFARA is a not for profit organization dedicated to delivering important new HIV/AIDS and Hepatitis information to as many interested people as possible, focusing on diverse populations and multiple levels of education in both patient and provider communities.

All programs shown on the Blog site www.IFARABLOG.org will appear with past conferences within a month on the IFARA Website: https://IFARA.info . The IFARA website contains further information about this year’s project including disclosure statements, Host site information and evaluation forms.
 

FDA Advises Serious Liver Disorder Associated with the Use of Videx/Videx EC (Didanosine)
AIDSinfo At-A-Glance Volume 6 Issue 4 (1.29.10)

"The U.S. Food and Drug Administration (FDA) is alerting healthcare professionals and patients about a rare, but serious, complication in the liver known as non-cirrhotic portal hypertension in patients using Videx or Videx EC (didanosine). Didanosine is a medication used to treat human immunodeficiency virus (HIV) infection. Videx was the first approved didanosine medication. Videx EC is a delayed-release version of Videx.

"Non-cirrhotic portal hypertension (portal hypertension that is not caused by cirrhosis of the liver) is rare in the United States. It occurs when blood flow in the major vein in the liver (the portal vein) slows down. This slowed blood flow can lead to the development of severely enlarged esophageal veins (varices) in the gastrointestinal system. Because esophageal varices are thin and portal hypertension increases the pressure of blood flow in these veins, esophageal varices can break open. This can result in serious bleeding and, in some cases, death.

"FDA became aware of cases of non-cirrhotic portal hypertension through adverse event reports submitted to FDA's Adverse Event Reporting System (AERS). Based on these reports, FDA has revised the didanosine drug label to include information about non-cirrhotic portal hypertension to help ensure the safe use of this drug.

"FDA believes the clinical benefits of didanosine for certain patients with HIV continue to outweigh its potential risks. The decision to use this drug, however, must be made on an individual basis between the treating physician and the patient."

Additional safety information regarding Videx/Videx EC (didanosine) can be found in the FDA press release.


 
 





 

IFARA CROI Blog

CROI updates will begin on the blog site on-demand February 16, 2010 direct from San Francisco

 

 

New from Journal Watch

 

HIV/AIDS Clinical Care for February 1, 2010

SUMMARY AND COMMENT

TB Recurrence: Reinfection or Relapse? Free!

February 1, 2010 | Carlos del Rio, MD

Recurrences after successful TB treatment are more common among HIV-positive than HIV-negative patients, and the reasons are different: About half the recurrences in HIV-positive patients represent reinfection rather than reactivation.

Reviewing: Crampin AC et al. AIDS 2010 Jan 28; 24:417

SUMMARY AND COMMENT

More from the DAD Study on Antiretrovirals and MI Risk

February 1, 2010 | Keith Henry, MD

An increased risk for myocardial infarction was found with recent exposure to abacavir and ddI and with cumulative exposure to abacavir, indinavir, and lopinavir/ritonavir.

Reviewing: Worm SW et al. J Infect Dis 2010 Feb 1; 201:318

Aberg JA and Ribaudo H. J Infect Dis 2010 Feb 1; 201:315

SUMMARY AND COMMENT

Isoniazid Prophylaxis in HIV-Infected Patients Free!

February 1, 2010 | Shahin Lockman, MD, MSc

HIV-infected patients who received isoniazid preventive therapy as part of a clinical trial in Botswana had low rates of incident tuberculosis and severe adverse events; adherence was quite high.

Reviewing: Mosimaneotsile B et al. J Acquir Immune Defic Syndr 2009 Nov 20;

SUMMARY AND COMMENT

No Benefit for Directly Observed Antiretroviral Therapy

January 21, 2010 | Bruce Soloway, MD

In a meta-analysis, viral suppression was similar in observed and nonobserved patients.

Reviewing: Ford N et al. Lancet 2009 Dec 19/26; 374:2064

Myers JE and Tsiouris SJ. Lancet 2009 Dec 19/26; 374:2030

 

 

See January

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